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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
16.36
Human Site:
S235
Identified Species:
30
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
S235
T
T
Q
L
R
L
L
S
E
D
T
D
S
Q
R
Chimpanzee
Pan troglodytes
XP_524538
437
47536
T239
S
L
S
F
K
H
L
T
E
D
K
A
N
K
R
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
S300
T
T
Q
L
R
L
L
S
E
D
T
D
S
Q
R
Dog
Lupus familis
XP_542963
571
61192
A370
T
T
Q
L
R
L
L
A
E
D
S
D
S
Q
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
S230
T
T
Q
L
Q
L
L
S
E
D
S
D
T
Q
R
Rat
Rattus norvegicus
Q62814
300
33206
L109
L
D
Q
Q
K
L
W
L
Q
Q
S
I
K
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
L247
I
Q
W
V
G
T
G
L
F
G
D
S
T
A
V
Chicken
Gallus gallus
Q90977
403
43534
T212
T
V
R
L
R
L
L
T
E
D
P
S
N
Q
H
Frog
Xenopus laevis
NP_001090608
426
47125
K227
N
T
Q
L
K
L
F
K
E
D
E
S
H
D
Y
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
N238
L
I
Q
T
C
T
R
N
V
Q
Q
M
T
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
Q362
E
N
L
A
E
I
S
Q
E
V
E
N
S
G
G
Honey Bee
Apis mellifera
XP_396223
416
46049
T225
D
L
E
A
K
E
N
T
L
D
R
L
I
H
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
A212
P
G
D
S
Q
L
S
A
E
T
V
N
L
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
26.6
100
86.6
N.A.
80
13.3
N.A.
0
53.3
40
6.6
N.A.
13.3
6.6
N.A.
13.3
P-Site Similarity:
100
60
100
100
N.A.
100
33.3
N.A.
13.3
73.3
46.6
26.6
N.A.
26.6
26.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
0
0
0
16
0
0
0
8
0
8
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
0
0
0
0
0
0
62
8
31
0
8
0
% D
% Glu:
8
0
8
0
8
8
0
0
70
0
16
0
0
8
8
% E
% Phe:
0
0
0
8
0
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
8
0
8
0
0
8
0
0
0
8
16
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
8
16
8
% H
% Ile:
8
8
0
0
0
8
0
0
0
0
0
8
8
0
0
% I
% Lys:
0
0
0
0
31
0
0
8
0
0
8
0
8
8
0
% K
% Leu:
16
16
8
47
0
62
47
16
8
0
0
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
8
0
0
0
0
8
8
0
0
0
16
16
8
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
8
54
8
16
0
0
8
8
16
8
0
0
39
0
% Q
% Arg:
0
0
8
0
31
0
8
0
0
0
8
0
0
0
39
% R
% Ser:
8
0
8
8
0
0
16
24
0
0
24
24
31
0
8
% S
% Thr:
39
39
0
8
0
16
0
24
0
8
16
0
24
0
0
% T
% Val:
0
8
0
8
0
0
0
0
8
8
8
0
0
0
16
% V
% Trp:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _